The MOUSE ANTI LIPOPROTEIN LIPASE Antibody from MyBioSource.com is a Mouse Monoclonal antibody to HDLCQ11, Lipoprotein lipase, and LPL. This antibody recognizes Human, Rat, Bovine, Chicken/Bird, and Guinea Pig antigen. The MOUSE ANTI LIPOPROTEIN LIPASE Antibody has been validated for the following applications: ELISA, Immunoprecipitation, and Western Blot.
Description
Mouse anti Lipoprotein Lipase antibody, clone 5D2 specifically recognizes an epitope within amino acids 380-410 of lipoprotein lipase (LPL), a member of the AB hydrolase superfamily, which plays a pivotal role in lipoprotein metabolism and transport, acting as the key enzyme in the hydrolysis of triglycerides and very low density lipoproteins (VLDLs), and the release of free fatty acids into peripheral tissues. A deficiency of LPL can result in hypertriglyceridemia, and many studies have focused on the critical role which LPL plays in the pathogenesis of atherosclerosis, and in particular the relationship between LPL and apolipoprotein E (ApoE), both of which are secreted in significant amounts by macrophages in developing arterial wall lesions. Mouse anti Lipoprotein Lipase antibody, clone 5D2 is a unique antibody which differentiates between monomeric inactive and dimeric active LPL, and binds to LPL sequences involved in LPL, LPL receptor, and heparin interactions. Mouse anti Lipoprotein Lipase antibody, clone 5D2 has been shown to inhibit the activity of human LPL (Chang et al. 1998)